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Wu Tsai Human Performance Alliance Seminar
Speaker: Nicos Haralabidis, Stanford University
Simulations Reveal How Touchdown Kinematic Variables Affect Top Sprinting Speed: Implications for Coaching
Abstract: Coaches often target kinematic variables, such as horizontal touchdown distance (HTD) and inter-knee touchdown distance (IKTD), when they are working to increase the top sprinting speed of athletes. However, prior findings on how HTD or IKTD affect top sprinting speed are conflicting, potentially due to existing studies relying on experimental inter-athlete study designs. In this talk, I will present results from a recent study that used predictive simulations to isolate how modifying HTD or IKTD influences top sprinting speed.
Speaker: Manoj Hariharan, Salk
DNA Methylation Dynamics in Skeletal Muscle Cell-types in Response to Endurance Exercise
Abstract: DNA methylation is an epigenetic modification that is known to regulate gene expression through the addition or removal of a methyl group on specific cytosine residues of DNA. Its role in muscle function, such as satellite cell activation, fibertype maintenance, and metabolic specialization, are well-studied. Given the heterogeneity of muscle, we implemented a genome-wide methylation assay to identify the DNA methylation dynamics of three different muscle tissues at single-nucleus resolution. The unique methylation profiles of groups of nuclei showed methylation signatures in canonical marker genes of various cell-types, also supported by single-nucleus-resolution transcriptomics. In this talk, I will highlight novel cell-type markers, and differential methylation across sedentary and active animals, at the level of the genome, genes, and regulons. Use of both female and male mice enabled the determination of sex-specific changes in endurance exercise, which will also be covered in the talk.
About the Seminar Series
The seminar series features speakers from across the institutions that make up the Alliance, covering topics related to our mission of uncovering the principles of performance and translating them to improved performance and care of athletes and all people.
The goal of the seminar series is to foster scientific exchange and the formation of new research collaborations through a set of research talks that are clear and compelling to researchers from a broad range of fields.
Please contact humanperformance@stanford.edu with any questions.