Agility Project Awardees [OLD]

Fatigue is a psychophysiological condition that plays a crucial role in sports by limiting athletes’ performance. Virtual reality (VR) systems have demonstrated potential for enhancing physical and cognitive training. Professor Heller and team will employ a VR system during physical exercise to simulate contrasting environments compared to real (non-VR) conditions while measuring physiological markers of fatigue and performance. The team believe the proposed work will enable them to quantitatively compare physiological and psychological contributions to fatigue, possibly leading to the development of more efficient training approaches for improving athletes’ performance and methods for improving acceptance of and enjoyment of physical activity as components of health improvement programs.

Digital models of the human body can allow us to measure and predict how our biology changes during training, injury, and aging. However, there are limited tools available for measuring dynamic changes in our heart and blood vessels. This project aims to develop a method for creating personalized digital models of the heart and blood vessels. Using measurements of arteries and blood flow through them from a new ultrasound-based wearable sensor, Professor Landay and team will fit a personalized digital model that describes how blood flows through an individual’s circulation. This personalized model can be used to study how hearts and blood vessels respond to exercise across the lifespan.

This project aims to understand how the body makes a taurine-related compound called N-acetyltaurine, which might help improve physical and mental performance. Taurine is an important part of our diet and is often found in energy drinks and pre-workout supplements. After humans consume taurine, it can be changed into different substances, like N-acetyltaurine which helps control energy balance and fat metabolism linked to taurine consumption. Professor Long will use studies on human cells and in mice to figure out which genes and pathways are involved in making N-acetyltaurine. By understanding the biological pathway that makes N-acetyltaurine, researchers could augment that pathway and produce more N-acetyltaurine or understand N-acetyltaurine deficits.

The complex community of microbes living in the digestive tract, known as the gut microbiota or microbiome, is influenced by many factors including exercise and diet. Microbiomes of athletes are distinct from average individuals and have been linked to enhanced physical performance. How athletic microbiomes evolve and the mechanism underlying microbial adaptation to exercise remain unknown. This project aims to define the links between the gut microbiome and exercise using mouse models, for example, exploring whether receiving an athletic microbiome can improve aerobic capacity. A deeper understanding of these connections will enable informed lifestyle changes and novel therapeutic avenues to improve athletic performance.

Little is known about the specific neural functions underlying the exceptional motor skill of expert musicians. Recent scientific discoveries have linked improved motor performance to reductions in excess neural synchrony – when large groups of neurons activate together across broad areas of the neural system. Dr. Tass and team hypothesize that in expert motor performance, selective neural activations and synchrony form the basis for precision of motor behavior, i.e., skill. Using vibrotactile coordinated reset stimulation, the team will investigate whether reductions in excess neural synchrony and functional connectivity serve both as a critical correlate for expert musicians’ skill, and as a promising pathway for interventions to further enhance this skill.

Bone health is an area of concern as humans age, since healing is slower and less effective in the elderly compared to younger populations. This project aims to understand how aging affects bone healing and to explore new ways to improve bone regeneration in older adults. Using cutting-edge tools like single-cell RNA sequencing, aged animal models, and computational genomics, Professor Yang and team will work to identify key cell types involved in healing and test new therapies for enhancing the regeneration of aged bone.

Managing fatigue is critical to ensure athletes are prepared for competition. However, research has highlighted the impracticality of exhaustive and time-consuming assessments to measure recovery and fatigue. In team sports, an effective instrument for fatigue monitoring should demonstrate sensitivity to training loads and their intensities while distinguishing acute exercise responses from long-term adaptations. Professor Coleman and his team will integrate these disparate modalities to arrive at a dynamic multi-modal description of recovery and fatigue in Stanford women’s basketball players. This research will help shed light on the dynamic process of how inflammation and recovery evolves to optimal recovery and peak performance at targeted times during the season in team sport.

Stress and growth mindsets play pivotal roles in achieving optimal performance and well-being. The project proposes the “Mindset Yoga” intervention, a unique blend of mindset education fortified by the self-awareness and regulation techniques fostered in yoga. We will rigorously assess the effectiveness of this combined approach against standalone Yoga and Mindset interventions. If proven effective, this methodology could be adapted for diverse groups, including athletes, the elderly, and individuals with various health conditions, aiming to bolster health, well-being, and performance during critical high-stress periods.

Brain injury is common among participants in many sports and is associated with cognitive decline that limits human performance. Disruption of the blood-brain barrier (BBB) is believed to play a critical role in this process, but many details remain unknown, and almost nothing is known about traumatic brain injury (TBI) during physical exertion. The proposed work introduces new imaging technologies to define the structural, biochemical, and cellular hallmarks of persistent BBB leakiness from repeated mild TBI during exercise. Furthermore, Professor Heilshorn and her team will test a novel therapy that they hypothesize will recruit pericytes to seal the damaged vessels and promote cognitive function.

The beginning of a heavy exercise program usually results in severe muscle soreness two or more days following the exercise. This condition, known as Delayed Onset Muscle Soreness (DOMS), results in the inability to engage in such exercise for 5 to 7 days. There is no clear explanation for DOMS that could lead to measures to prevent this sequalae of events. In past work, Professor Heller and his team have shown palmar cooling extracts heat from the body during exercise and greatly increases work volume and rate of physical conditioning without causing DOMS. The team will test whether intermittent palmar cooling during heavy exercise results in large physical conditioning gains without DOMS.

Lower-limb exoskeletons have advanced in their ability to improve human performance through assisting, rehabilitating, and augmenting wearers. A key challenge that remains is detecting a user’s intent to adapt to new scenarios, such as walking on flat ground versus steps or ramps. This causes a delay in the exoskeleton response which can lead to user strain and instability in the worst cases. To address this, this project proposes to use the state-of-the-art adaptive ankle exoskeleton coupled with environment-based path predictions to predict the wearer’s expected path and upcoming changes in terrain. Such a system could enable smoother transitions between terrain types, resulting in improvement in overall assisted walking performance.

This project proposes a novel, widely accessible intervention to promote strength training and improve cognitive, psychological, and behavioral performance at work. The intervention, referred to as  “strength snacks,” interrupts prolonged sitting with 3-4 short, progressive strength-training bouts with no equipment and simple video-based instructions. The study will assess human performance outcomes across multiple domains: physical, biological, cognitive, psychological, and behavioral.

The current design of the piano keyboard, largely unchanged since the late 19th century, disproportionately puts women at higher injury risk and limits their professional opportunities due to ergonomic imbalance. This research project explores the relationship between hand size, keyboard size, and performance quality using a generative artificial intelligence (AI) model to produce precise predictions of the motions and forces required to reproduce a piano performance. These new insights can inform instrument design and teaching methods, thereby leveling the playing field for women in piano performance. This research has the potential to be a catalyst for change, not just in music, but in any field where ergonomic design influences peak human performance.

It is well documented that we lose 10% muscle mass each year starting in our forties, a condition called sarcopenia. This muscle loss is linked to a spontaneous mutation in our mitochondrial DNA. This project will use extracellular vesicles to deliver healthy mitochondria and their DNA to the weakened muscles and related organs in hopes of rejuvenating them and eventually translating the findings to a phase I clinical trial.

Human performance is strongly impacted by physical and mental wellness. Current mental health testing primarily relies on self-reporting late-stage symptoms. The team’s long-term goal is to develop a precision mental health tool to quantitatively track related biomarkers like cortisol and serotonin, for stress and mood, respectively. They hypothesize that a continuous measurement skin-patch that samples the dermal interstitial fluid (ISF) can provide continuous and more accurate measurements, as compared to sweat and saliva-based methods. The team will adapt and validate its flexible cortisol and serotonin sensors for dermal ISF measurements. This work will enable a way to quantitatively monitor stress and understand its correlation with athlete performances.

The age-associated loss of muscle mass and function is known as sarcopenia, a debilitating disease for older persons. Dr. Blau and her lab recently discovered that the levels of a cellular component, prostaglandin E2 (PGE2), correlate with muscle regeneration and greater endurance in aged mice. By contrast, reducing PGE2 levels in young mice prematurely ages their muscles. PGE2 levels are controlled by an enzyme called 15-PGDH, which can be manipulated by a small molecule drug. This project’s goal is to survey older adults with and without sarcopenia and determine whether their personal levels of 15-PGDH and PGE2 correlate with strength, as in mice. This is a necessary first step toward translating our mouse sarcopenia therapeutic to humans.

Head impacts are known to affect the brain, with both short- and long-term consequences. Even a single impact can have important long-term consequences, leading to chronic neuro-degeneration or earlier onset of dementia. Unfortunately, the process of brain injury and local or global degeneration resulting from the impact is not well understood. The objectives of this study are to develop a large animal model of traumatic brain injury (TBI) replicating human TBI pathology and to link neuroimaging and biomechanics with histopathology, to inform a model in humans based on impact exposures and/or neuroimaging.

Anterior cruciate ligament (ACL) tear is a common sports knee injury frequently affecting young adults, leading to premature development of pain and stiffness from osteoarthritis. Using patient samples, advanced MRI scans, and clinical outcomes from ACL injured patients, the research team will determine whether inflammatory cells and proteins associated with osteoarthritis reduce performance recovery after ACL reconstruction. This research hopes to contribute new therapeutic targets to improve athletic longevity, joint health, and human performance.

30-90% of endurance athletes report GI symptoms during training or competition. Further, optimal timing of dietary intake to absorb nutrients or counter hydration loss in endurance sports depends on the rate of gastric emptying. For female endurance athletes, the menstrual cycle affects gastric emptying as well; it is slower during the follicular phase as compared to the luteal phase. The aim of this project is to build a soft, stretchable wearable system that provides personalized information about gastric emptying rate. Such a system could enable dietary intake optimization for female endurance athletes during all phases of their menstrual cycle for training and competition.

Running is the most popular form of aerobic exercise in the United States, but knee joint pain sidelines many runners. Exoskeletons could assist the knee, offloading muscles and reducing the joint loads that cause pain. This project aims to develop a running knee exoskeleton, methods for estimating running knee loads, and algorithms to optimize exoskeleton assistance to minimize knee joint loads by 40 to 60%, potentially eliminating pain associated with running. These results will yield new insights into the interactions between robotic assistance, muscle activity, joint loads, and pain during running–exciting new dimensions in human performance enhancement.

The team’s long-term goal is to embed miniature lattice pressure sensor arrays in biomedical devices to enable a multitude of continuous human health monitoring systems, such as non-invasive heart rate and pulse monitoring, activity monitoring, impact, and gait sensing. The first step toward achieving this objective is to understand the fundamentals of each lattice structure and its effect on pressure sensor performance. This research project seeks to design and fabricate latticed dielectric layers for a new generation of pressure sensor arrays, and to characterize their stress-strain responses, with fabrication enabled by a high-resolution 3D printer designed and built recently here at Stanford.

It is common for athletes to suffer from skeletal muscle injury, the recovery from which is essential for the athletes’ quality of life and return to peak performance. Mesenchymal stem cell (MSC) transplantation is a promising therapy for such recovery, yet its efficacy is hindered by the poor survival rates of the transplanted cells and our limited capabilities to control the local immune response. This project will utilize a novel molecular design that can target the implanted cells or the niche inhabited by them. Their proposed strategy may lead to effective and consistent improvements for clinical translation, and therefore have an impact for the performance of athletes.

The close relationship between humans and the commensal microbes of their gut microbiota represents vast potential for health maintenance, but most efforts have been focused on disease. Lifestyle choices, such as diet, play key roles in health, and recent studies focused on feces have suggested that exercise can enrich the microbiome. This project will utilize a novel, non-invasive sampling technology to quantify the effects of exercise on the gastrointestinal environment and the potential to ameliorate negative impacts of exercise on the gut using fermented foods and high-throughput immune profiling. These efforts could establish the potential for dietary and thermal interventions to improve recovery from exercise.

Nutritional supplements, like ketone esters, are important for optimizing sports performance. Drinking ketone ester sports drinks has been shown to improve endurance and athletic performance. But exactly how these drinks lead to better sports performance has remained mysterious. BHB-amino acids could provide a key molecular clue to understand why ketone ester drinks improve athletic performance and metabolic health. This project will use a combination of chemistry, mouse models, and human studies to determine how BHB-amino acids are made. The research team will also determine how BHB-amino acids alter glucose metabolism and identify the network of proteins with which BHB-amino acids interact. 

Learning new motor skills is crucial to human performance. However, traditional neuroimaging studies of human motor skill learning typically do not take into account individual variability in the functional architecture of the brain, nor do they densely collect data during the intermediate stages of learning. This project aims to overcome these limitations by creating complete and precise brain maps of motor skill learning through the use of precision neuroimaging approaches. The resulting brain maps will have the potential to spark new translational applications of human motor skill learning research to human performance, such as in movement rehabilitation, sports training, and the use of prosthetics.